Miniaturized immunopeptidomics workflow for target discovery from scarce samples

In her talk, Yoanna explains how the low abundance of pHLA complexes in immunopeptidomics often demands large sample inputs, limiting accessibility and throughput. She introduces a miniaturized, automation-ready protocol that enables robust peptide profiling from limited material. This workflow supports both discovery and targeted acquisition strategies, making scalable immunopeptidomic analysis possible across diverse sample types.

Talk highlights:

Workflow Development and Rationale
Comparative Analysis of Homogenizers
Case Studies for Benchmarking of Miniaturized Workflow

Yoanna compares three tissue homogenizers using kidney and lung tissues of varying sizes and cancer cell lines. The BeatBox^® delivers more consistent results for the miniaturized immunopeptidomics workflow, demonstrating robust performance across sample types.

The BeatBox is a fast and easy to use instrument for up to 96 samples, which completes the homogenization in as little as 10 minutes without sample cross contamination and minimal heat induction. The BeatBox has a surprisingly small footprint and quiet operation in comparison to traditional tissue processing machines. With the BeatBox, tissue homogenization and cell lysis can be integrated into the PreOmics^® iST sample preparation workflows.

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Miniaturized immunopeptidomics workflow for target discovery from scarce samples

SUMMARY OF THE TALK

Yoanna Ariosa-Morejon
Senior Research Scientist
Immunocore, UK

THE SOLUTION

HOW CAN WE SUPPORT YOUR NEEDS?

Fill in the form to access the talk

Miniaturized immunopeptidomics workflow for target discovery from scarce samples

SUMMARY OF THE TALK

Yoanna Ariosa-MorejonSenior Research ScientistImmunocore, UK

THE SOLUTION

HOW CAN WE SUPPORT YOUR NEEDS?

Yoanna Ariosa-Morejon
Senior Research Scientist
Immunocore, UK