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Proteomics User Group Meeting
for UK/Ireland & Nordics
A virtual afternoon of talks, discussions and exchanges between scientists interested in tissue homogenization & cell lysis in proteomics
Virtual
Now available on-demand
OVERVIEW
Proteomics User Group Meeting for UK/Ireland & Nordics
We invite you to register for our first Proteomics UK/Ireland & Nordics User Group Meeting on tissue and cell proteomics. Connect with fellow scientists, share best practices, and discover how BeatBox is driving advancements in your field. All from the comfort of your desk!
Explore how the BeatBox sample homogenizer fits into diverse LC-MS proteomics workflows and learn how it pairs with PreOmics’ iST technology for complete sample prep solutions.
AGENDA
Welcome & Introduction
Adam Hughes, Key Account Manager, Northern Europe, PreOmics
High-throughput proteomic analysis of FFPE lung tissues: Enhancing reproducibility and speed with the BeatBox®
Esen Efeoglu, Assistant Lecturer in Pharmaceutical Chemistry, School of Food Science and Environmental Health at Technological University Dublin, Ireland
Miniaturized immunopeptidomics workflow for target discovery from scarce samples
Yoanna Ariosa-Morejon, Senior Research Scientist at Immunocore, UK
Deep palaeoproteomic profiling of archaeological human brains
Alexandra Morton-Hayward, DPhil Molecular Taphonomy & Forensic Anthropologist (III), Palaeobiology Group, Department of Earth Sciences, University of Oxford, UK
Using metaproteomics to unravel differences in the gut microbiome through fecal bioreactor fermentations
Kristian Jensen Pedersen, Analytical Scientist at Cmbio, Denmark
Live Q&A session
Open questions to the speakers and PreOmics team
SPEAKERS & ABSTRACTS
Esen Efeoglu, Assistant Lecturer in Pharmaceutical Chemistry, School of Food Science and Environmental Health at Technological University Dublin, Ireland
Comprehensive proteomic profiling of lung cancer is crucial for elucidating tumour biology, identifying biomarkers, and advancing precision medicine approaches in one of the leading causes of cancer mortality worldwide. Formalin-fixed paraffin-embedded (FFPE) tissues constitute a rich archive for retrospective clinical proteomics, yet their biochemical complexity poses major challenges for efficient protein recovery and quantification. In this study, we performed deep proteomic profiling of patient-derived FFPE lung cancer and matched adjacent normal tissues using an optimised sample preparation workflow utilising a combination of Beatbox Technology and PreOmics iST kit. Subsequent LC-MS/MS analysis revealed distinct proteomic signatures associated with tumour versus normal tissue, highlighting the biological insights that can be extracted from archived specimens when robust and standardised workflows are employed.
Yoanna Ariosa-Morejon, Senior Research Scientist at Immunocore, UK
Immunopeptidomics typically requires large sample input due to the low abundance nature of pHLA complexes, limiting accessibility and throughput. We developed a miniaturized, automation-compatible protocol that enables robust peptide profiling from scarce material. This workflow supports both discovery and targeted acquisition strategies. It facilitates scalable immunopeptidomic analysis across diverse sample types.
Alexandra Morton-Hayward, DPhil Molecular Taphonomy & Forensic Anthropologist (III), Palaeobiology Group, Department of Earth Sciences, University of Oxford, UK
More than 4,400 human brains up to 12,000 years old have been unearthed by archaeologists in the last four centuries. Whereas decay experiments suggest that the nervous system is amongst the first organs to decompose, less than 1% of this material has been investigated at the molecular level and brain biochemistry has been little studied beyond several days after death. We present the initial findings of our palaeoproteomic analyses of ancient preserved human brains, which point to the role of the organ's unique biochemistry in its preservation: specifically, the parts played by intrinsically disordered and membrane-bound proteins, and the way in which their transformation after death parallels brain ageing phenomena during life. We discuss the value of preserved brains for bioarchaeological science, and how to maximise the wealth of molecular and morphological information they harbour after death.
Kristian Jensen Pedersen, Analytical Scientist at Cmbio, Denmark
Bacterial pellets harvested from bioreactors inoculated with human fecal material and exposed to defined combinations of dietary fibers, proteins, and polyphenols were subjected to metaproteomics. Implementation of the SP3-IST PreOmics workflow on our TIMS-TOF Pro2 enabled relative quantitation and identification of approximately 35,000 peptides, corresponding to ~15,000 distinct proteins. These datasets demonstrate the power of metaproteomics to resolve both taxonomic and functional features of complex microbiomes, reaching strain-level resolution and response to dietary interventions.
Adam Hughes, Key Account Manager, Northern Europe, PreOmics
Adam joined PreOmics in 2024 as Key Account Manager for Northern Europe, with over 15 years of experience in the life sciences industry. Adam focuses on separation science, particularly sample preparation and chromatography, helping customers optimize their workflows and achieve reliable, reproducible results. His background includes a Master’s degree in Chemistry and an MBA with the Open University, blending scientific expertise with commercial insight.
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